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Model studies on self-assembly of amphiphilic macro-molecules with solvent exposed hydrophobic moieties

Venerdì 11 gennaio 2019, ore 11.30, aula Seminari, terzo piano, edificio Fisica, Dipartimento FIM, Modena

Relatore: Sutapa Dutta (Department of Chemical Biological & Macro-molecular Sciences, S. N. Bose National Centre for Basic Sciences Block JD, Sector III, Salt Lake, Kolkata-700106, WB, India)

Abstract: Self-assembly at nano-meter length scale by amphiphilic molecules are relevant not only in several neurodegenerative disorders but also in nano-bio technology. Here, we study protein aggregation using a model system of particles having charge at the core but with solvent repelling surface using Monte-Carlo (MC) simulations and mean field analytical treatment. We observe from our simulations that the hydrophobic particles with mutual harmonic interaction of strength α , exhibit aggregation. Electrostatic repulsion between the particles characterized by Debye screening length κ−1 , controls stability of finite clusters or aggregates, the threshold of aggregation being α ~ κ−1.5 . We support our observations qualitatively from mean field analysis.

Host: Giorgia Brancolini giorgia.brancolini@nano.cnr.it

[Ultimo aggiornamento: 01/04/2021 12:45:23]