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Irreversible gating transitions in TRPV1 ion channels

Giovedì 28 giugno 2018, ore 12.00, aula Seminari, S3 Cnr Nano, terzo piano, edificio Fisica, Dipartimento FIM, Modena

Relatore: Leon Islas (Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, México).

Abstract: Temperature activated TRP channels or thermoTRPs are among the only proteins that can directly convert temperature changes into changes in channel open probability. In spite of a wealth of functional and structural information, the mechanism of temperature activation remains unknown. We carefully characterize the repeated activation of TRPV1 by thermal stimuli and discovered a previously unknown inactivation process, which is irreversible. We propose that this form of gating in TRPV1 channels is a consequence of the heat absorption process that leads to channel opening and might reflect partial unfolding of one or more regions of the protein.

Host: Andrea Alessandrini andrea.alessandrini@unimore.it

[Ultimo aggiornamento: 08/06/2018 15:23:01]